| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5905244 | Gene | 2016 | 29 Pages |
Abstract
The rs6523 polymorphism and AGAG haplotype of INSL3 showed significant association with increased risk of PCOS. Additionally, INSL3 polymorphisms influenced metabolic and hyperandrogenemia related parameters in both controls and PCOS women. This is the first study to suggest that INSL3 may be a genetic predisposition factor in PCOS pathophysiology.
Keywords
FAIINSL3QUICKIPCOSOGTTHDL-CWHRGDF-9HOMA-IRApoA-1SHBGFBSapo BApolipoprotein A-1Apolipoprotein BAssociationhomeostasis model assessment of insulin resistanceTriglyceridesbioavailable testosteronefree testosteronePolycystic ovary syndromefree androgen indexbody mass indexBMIquantitative insulin sensitivity check indexInsulin-like factor 3growth differentiation factor 9fasting blood glucosehigh-density lipoprotein cholesterolLow-density lipoproteinLDLTotal testosteroneUTR یا untranslated regions untranslated regionWaist to hip ratiosex hormone binding globulinpolymerase chain reactionPCRPolymorphismGenetic
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Authors
Nuzhat Shaikh, Roshan Dadachanji, Pervin Meherji, Nalini Shah, Srabani Mukherjee,