| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5905328 | Gene | 2015 | 8 Pages |
Abstract
Furthermore, C2C12 cells expressing ÎPR-PRDM16 exhibited significant differences in histone modifications on the promoters of MyoD and PPARγ genes. Taken together, PRDM16-induced C2C12 transdifferentiation is associated with alterations in CpG methylation of myogenic factors, and PR domain affects both myogenesis and adipogenesis with modified histone methylation marks on MyoD and PPARγ promoters.
Keywords
PRDM16SIX1MCKMyogenesisH3K4me3MyHCPPARγPR domainMEFTSSNFATC/EBPAdipogenesischromatin immunoprecipitationtranscription start siteMyosin heavy chainNuclear Factor of Activated T Cellsmuscle creatine kinasehistone H3 lysine 4 trimethylationCCAAT/enhancer binding proteinCHiPperoxisome proliferator-activated receptor γ
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Authors
Xiao Li, Jinquan Wang, Zheng Jiang, Feng Guo, Paul D. Soloway, Ruqian Zhao,