Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5905369 | Gene | 2015 | 6 Pages |
Abstract
Fc receptor-like 3 (FCRL3) has recently been associated with susceptibility to several immune-related diseases. In this study, we evaluated the potential association of FCRL3 polymorphisms with sudden sensorineural hearing loss (SSNHL) in a Chinese Han population. Five single-nucleotide polymorphisms (SNPs) in FCRL3-rs945635, rs3761959, rs7522061, rs10489678, and rs7528684-were genotyped in 630 patients with SSNHL and 600 healthy controls by using a PCR-restriction fragment length polymorphism assay. The allele, genotype, and haplotype frequencies in the patients and the controls were compared using a Ï2 test. Moreover, we performed haplotype analysis by using the online software platform SHEsis. The results revealed a significant association between three SNPs-rs7528684, rs3761959, and rs7522061-and SSNHL in the studied Chinese Han population. Furthermore, the AGT and GAC haplotypes were associated with a significantly higher prevalence of SSNHL than were the GAT, GGC and GGT haplotypes. However, no significant differences were detected in either the genotype or allele frequencies of the other two SNPs, rs945635 and rs10489678, between the SSNHL and control groups. Overall, this study has identified an association between FCRL3 polymorphisms and increased risk of SSNHL in a Chinese Han population.
Keywords
SDSmAbCCCCATCPMRDNARBSORFIPTGDTTSSCPPITSPMCskDaPPORFLPPAGEdeoxyribonucleaseHSVPMSFdNTPAMVG418HprtTMVLTRXgaldeoxyriboCytidineRNaseoligodeoxyribonucleotideONPGURFN6-methyladenosinemitochondria(l)rRNAPGalgene encoding CATEtdBrlacZpolac promoter-operatornicotinamide-adenine dinucleotide and its reduced formPollkunidentified open reading framePolyacrylamide′ (prime)Kilobase(s) or 1000 bp1,4-piperazinediethanesulfonic acid2,5-DiphenyloxazoleBSAcAMPcDNAcIAPDMSODNA methyltransferaseDNA complementary to RNADNA coding for rRNADNAsekiloDalton(s)m6AMOImonoclonal AbORIRibosomal RNAAdenosinecyclic adenosine 3′,5′-monophosphateAdenovirusbovine serum albuminCalf intestinal alkaline phosphataseAmpicillinamino acid(s)antibody(ies)novel junction (fusion or insertion)ethidium bromideUridineErythromycinS-adenosylmethionineSteroidStreptomycinCm acetyltransferaseUltravioletPA-gel electrophoresisoligoOperatorimmunoglobulin(s)interferonIFNinterleukinRecombinantChoTetracyclineChinese Hamster OvaryTransposoninsertion sequence(s)long terminal repeat(s)ELISAEnzyme-linked immunosorbent assaysingle strand(ed)Thymidinethymidine kinaseThiostreptonBase pair(s)Gentamicindeletiondeoxyribonucleoside triphosphatere-dithiothreitolDimethylsulfoxidesedimentation constantdouble strand(ed)transcription start point(s)ribonucleaseRifampicinribosome-binding site(s)Chloroplastsodium dodecyl sulfatecounts per minuteelongation factor Initiation factorinorganic phosphatephenylmethylsulfonyl fluorideopen reading frameKlenow (large) fragment of E. coli DNA polymerase ILuria–Bertani (medium)PipesRestriction endonucleaseorigin(s) of DNA replicationUTR یا untranslated regions Myrmillion yearsdenotes prophage (lysogenic) statedenotes plasmid-carrier statedenotes a truncated gene at the indicated sidewild typeNeomycinnucleotide(s)Haplotypeany nucleosidehypoxanthine-guanine phosphoribosyl transferasehygromycinunit(s)plaque-forming unit(s)avian myeloblastosis virusTobacco mosaic virusHIVhuman immunodeficiency virusherpes simplex virusterminator of transcriptionPromoterpfuPlasmidPoly(ethylene glycol)Single-nucleotide polymorphismrestriction-fragment length polymorphismPEGinorganic pyrophosphatePyrimidinemultiple cloning site(s)multiplicity of infectionGeneticinKanamycinRifHPLChigh-performance liquid chromatographyChloramphenicolcovalently closed circularguanosine
Related Topics
Life Sciences
Biochemistry, Genetics and Molecular Biology
Genetics
Authors
Hong Liu, Zheng Gu, Hou-Yong Kang, Xia Ke, Yang Shen, Xiao-Qiang Wang, Guo-Hua Hu, Ji-Hong Zeng, Su-Ling Hong,