Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5905503 | Gene | 2014 | 6 Pages |
Abstract
The Rhodopsin family is a class of integral membrane proteins belonging to G protein-coupled receptors (GPCRs). To date, several orphan GPCRs are still uncharacterized and in this study we present an anatomical characterization of the GPR162 protein and an attempt to describe its functional role. Our results show that GPR162 is widely expressed in GABAergic as well as other neurons within the mouse hippocampus, whereas extensive expression is observed in areas related to energy homeostasis and hedonic feeding such as hypothalamus, amygdala and ventral tegmental area, regions known to be involved in the regulation of palatable food consumption.
Keywords
3CbPerifornical nucleusHedonic feedingBLVdorsomedialVTAGPCRsACOLPOCPURMCBLABMAAcbVentral pallidumPirOlfactory tubercleSIMdentate gyruspiriform cortexArcLateral preoptic areaventral tegmental areaaccumbens nucleusanterior cortical amygdaloid nucleusMedial mammillary nucleuslateral hypothalamic nucleusarcuate hypothalamic nucleusEnergy homeostasisCaudate putamen
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Authors
Vanni Caruso, Maria G. Hägglund, Luca Badiali, Sonchita Bagchi, Sahar Roshanbin, Tauseef Ahmad, Helgi B. Schiöth, Robert Fredriksson,