Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5905767 | Gene | 2014 | 7 Pages |
Abstract
Diabetes mellitus (DM) is a major health problem worldwide and it will rapidly increase. This disease is characterized by hyperglycemia caused by defects in insulin secretion, insulin action or both. DM has three types: T1DM, T2M and gestational DM (GDM), of them T2DM is more frequent. Multiple genes and their interactions are involved in insulin secretion pathway. Sulfonylurea receptor encoded by ABCC8 gene, together with inward-rectifier potassium ion channel (Kir6.2) regulates insulin secretion by ATP-sensitive K+ (KATP) channel located in the plasma membranes. Disruption of these molecules by different mutations is responsible for risk of DM. Several single nucleotide polymorphisms (SNPs) of ABCC8 gene and their interaction are involved in pathogenicity of DM. This review summarizes the current evidence of contribution of ABC8 genetic variants to the development of DM.
Keywords
Forkhead box A2KCNJ11FOXA2TMDNBDT1DMGDMPurkinjeATP-sensitive K+KATPKir6.2ABCC8Calpain 10PPARγLVAHPLSNPsVDCCEnsaSUR1Residualnucleotide-binding domainsTransmembrane domainsGestational diabetes mellitusDiabetes mellitustype 1 diabetes mellitusType 2 diabetes mellitusLong-lastingNeuralHuman placental lactogenGenome-wide association studiesGWAShigh-voltage activatedPolymorphismSingle nucleotide polymorphismsHVAvoltage-gated calcium channelsLow-voltage activatedTransientsulfonylurea receptorPeroxisome proliferator-activated receptor-γ
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Authors
Polin Haghverdizadeh, Monir Sadat Haerian, Pantea Haghverdizadeh, Batoul Sadat Haerian,