Heterogeneous surfaces to repel proteins

•We summarize the recent achievements and discuss the new perspectives in the research of developing heterogeneous surfaces to repel proteins.•We discuss the protein repulsion mechanisms behind heterogeneous surfaces.•We outline the perspective and challenge of heterogeneous surfaces as the next-generation protein-repulsive materials.

The nonspecific adsorption of proteins is usually undesirable on solid surfaces as it induces adverse responses, such as platelet adhesion on medical devices, negative signals of biosensors and contamination blockage of filtration membranes. Thus, an important scheme in material science is to design and fabricate protein-repulsive surfaces. Early approaches in this field focused on homogeneous surfaces comprised of single type functionality. Yet, recent researches have demonstrated that surfaces with heterogeneities (chemistry and topography) show promising performance against protein adsorption. In this review, we will summarize the recent achievements and discuss the new perspectives in the research of developing and characterizing heterogeneous surfaces to repel proteins. The protein repulsion mechanisms of different heterogeneous surfaces will also be discussed in details, followed by the perspective and challenge of this emerging field.

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