Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5906210 | Gene | 2013 | 36 Pages |
Abstract
In this article the special emphasis is to discuss the strategies of regulation of gene expression by endogenous stimuli. Particularly, the hypoxia- or miRNA-regulated vectors offer the possibilities of tight but, at the same time, condition-dependent and cell-specific expression. Such means have been already tested in certain pathophysiological conditions. This creates the chance for the translational approaches required for development of effective treatments of so far incurable diseases.
Keywords
EPOTETIPSCsHO-15-FCHeme oxygenase-1HIFNrf2HRETTADBDTTSBVRrtTAOxygen dependent degradation domainMLC2vHSC3′untranslated region3′UTR5-fluorocytosineROSerythropoietintetracycline operatorWASbiliverdin reductasetetracycline repressorTetracyclinetetrtetOOxidative stressDNA binding domainPhDshematopoietic stem cellsInduced pluripotent stem cellsWiskott–Aldrich syndromeCytosine deaminaseantioxidant response elementhypoxia response elementVascular endothelial growth factorVascular Endothelial Growth Factor (VEGF)Hypoxia Inducible FactorODDKeap 1MicroRNAMiRNAAREHypoxiaHerpes simplex virus thymidine kinaseprolyl hydroxylasesGalactocerebrosidaseGalCReactive oxygen species
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Authors
Agnieszka Jazwa, Urszula Florczyk, Alicja Jozkowicz, Jozef Dulak,