Complex genetic susceptibility to vascular dementia and an evidence for its underlying genetic factors associated with memory and associative learning

Article ID	Journal	Published Year	Pages	File Type
5906781	Gene	2013	6 Pages	PDF

Abstract

âº Genetic factor for vascular dementia is hardly identified even by genomewide study. âº Its potential false negatives were associated with memory and associative learning. âº Statistical and functional genomics would light its underlying genetic factors.

Keywords

GSN IL6 MMP9 CST3 TGFB1 GSTO1 IL1b MMP3 matrix metallopeptidase 3 IL1A MTHFR HSPA1A TNFSF14 FAM134B MMP1 PON2 FDA TNF SREBF2 TTR PON1 ACE IGF1R APP ICAM1 CADASIL VLDLR Angiotensin I converting enzyme Angiotensinogen Apoe apolipoprotein E Interleukin 1 alpha interleukin 1 beta interleukin 6 genomewide association study Syk Complex disease transforming growth factor beta 1 TTR, Transthyretin Vascular dementia Cystatin C spleen tyrosine kinase Vascular endothelial growth factor Vascular Endothelial Growth Factor (VEGF)tumor necrosis factor matrix metallopeptidase 9 Methylenetetrahydrofolate reductase GWAS Intercellular adhesion molecule 1 false discovery rate NOTCH3 AGT Paraoxonase 1 Paraoxonase 2 Single nucleotide polymorphism Gelsolin Androgen Receptor insulin-like growth factor 1 receptor Very low density lipoprotein receptor