| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5907036 | Gene | 2012 | 9 Pages |
Abstract
⺠We found that DHRS2 and DHRS4 genes are syntenic outparalogues. ⺠DHRS2 originated from the DHRS4 gene by duplication. ⺠The duplication occurred before the formation of the mammalian clade. ⺠DHRS2 gene underwent positive selection on more sites than the DHRS4 gene. ⺠Substrate specificity drove the functional divergence from the DHRS4 enzyme.
Related Topics
Life Sciences
Biochemistry, Genetics and Molecular Biology
Genetics
Authors
Franco Gabrielli, Sergio Tofanelli,