| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5907364 | Gene | 2012 | 16 Pages |
Abstract
⺠We cloned a previously unpublished 4 kb tau (MAPT) gene promoter region. ⺠We further analyzed the 4 kb sequence via EMSA and CAT reporter gene clone series. ⺠The MAPT sequence was for the less common H2 haplotype. ⺠EMSA showed potentially important transcription factor interactions. ⺠Reporter clone series revealed promoter regulatory domains.
Keywords
CREBmyelocytomatosis viral oncogene homologchloramphenicol acetyltransferase geneE2F4PDEFcMYCRARCrhr1PC12HREHIFMAPTFTDAPPNRLTSSCATAβC/EBPApoeAlzheimer's diseaseParkinson's diseaseGene regulationTauneural retina leucine zipperEMSA یا electrophoretic mobility shift assay Transcription factorNuclear factor κ BHypoxia responsive elementHypoxia-inducible factorfrontotemporal dementiamareUTR یا untranslated regions neurofibrillary tanglesbase-pairAmyloid β peptideCCAAT/enhancer binding proteinspecificity proteinactivator proteinPromoterapolipoprotein E geneEstrogen receptorRetinoic acid receptorProgesterone receptor
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Authors
Bryan Maloney, Debomoy K. Lahiri,