| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5907388 | Gene | 2012 | 6 Pages |
Abstract
⺠HP CNV/HPR SNP haplotype analysis shows association of HP CNV with Hb levels/RCC. ⺠HP CNV/HPR SNP haplotype analysis shows association of HPR SNP with LDL-C/TC. ⺠The HP CNV/Hb-related association may be via Hp2 allele advantage in malaria zones. ⺠The HPR SNP/cholesterol association is likely via apolipoproteins in TLF-1 and -2. ⺠We infer that HP CNV duplication preceded HPR SNP mutation.
Keywords
haptoglobin geneARCsRCCCHDHTRHDL-CHPRLDL-CApo-APASWCNVExpectation Maximizationcoronary heart diseaseTrypanosomeLinkage disequilibriumMalariaGenome-wide association studyGWASCopy number varianthaemoglobinpolymerase chain reactionPCRSingle nucleotide polymorphismSNPcholesteroltotal cholesterolhigh density lipoprotein cholesterollow density lipoprotein cholesterolkilo Daltons
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Authors
Philip A.I. Guthrie, Santiago Rodriguez, Tom R. Gaunt, Debbie A. Lawlor, George Davey Smith, Ian N.M. Day,