| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5907456 | Gene | 2012 | 5 Pages |
Abstract
⺠We examined SREPB pathway regulation in FH-Fibroblasts. ⺠SREBP-2 activates SR-BI expression in FH-Fibroblasts. ⺠SREBP-2 mediated ABCA1 expression is decreased in homozygous FH-Fibroblasts. ⺠Cholesterol pools regulate SREBP-2 function for ABCA1 transcription in FH.
Keywords
ABCA1SREBPINSIG-1SR-BISRENPCLDLRHMGCRHDLGAPDHRTPCRSCAPATP binding cassette transporter A1HMG-CoA reductaseNiemann–Pick disease type CTangier diseasehigh density lipoproteinlow density lipoproteinLDLFamilial hypercholesterolemiareverse transcription polymerase chain reactionSterol regulatory element-binding proteinsrebp cleavage-activating proteinglyceraldehyde-3-phosphate dehydrogenaseLDL receptorscavenger receptor class B type I
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Authors
Muhidien Soufi, Volker Ruppert, Bilgen Kurt, Juergen R. Schaefer,