Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5907587 | Gene | 2011 | 8 Pages |
Abstract
⺠EROD was not detected in Pterygoplichthys liver microsomes ⺠CYP1A protein and mRNA were induced by treatments with AhR agonists. ⺠CYP1A coding region exhibits six exclusive amino acids substitutions. ⺠EROD substrate docked infrequently and in an unusual position at the active site.
Keywords
RMSDCYP1AERODi.p.DMBARMSBNFethoxyresorufin-O-deethylaseNADPHSRSPDBRMSFPCB126ITSTRISqPCR7,12-dimethylbenz[α]anthraceneAHRDMSOInternal transcribed spaceramino acidEthoxyresorufinRoot-mean-squared deviationTris(hydroxymethyl)aminomethaneSubstrate specificityIntraperitoneallyMolecular dynamicsDimethyl sulfoxidequantitative real time PCRBiotransformationsubstrate recognition sitecytochrome P450 1aroot mean squarepolymerase chain reactionPCRProtein Data Bankoptical densityreduced nicotinamide adenine dinucleotide phosphatearyl hydrocarbon receptor
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Authors
Thiago E.M. Parente, Mauro F. Rebelo, Manuela L. da-Silva, Bruce R. Woodin, Jared V. Goldstone, Paulo M. Bisch, Francisco J.R. Paumgartten, John J. Stegeman,