Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5908079 | Genomics | 2008 | 6 Pages |
Abstract
The comparative genomics of the Odf1, Prm1, Prm2, Tnp1, and Tnp2 genes in 13-21 diverse mammalian species reveals striking similarities and differences in the sequences that probably function in the transcriptional and translational regulation of gene expression in haploid spermatogenic cells, spermatids. The 5â² flanking regions contain putative TATA boxes and cAMP-response elements (CREs), but the TATA boxes and CREs exhibit gene-specific sequences, and an overwhelming majority of CREs differ from the consensus sequence. The 5â² and 3â² UTRs contain highly conserved gene-specific sequences including canonical and noncanonical poly(A) signals and a suboptimal context for the Tnp2 translation initiation codon. The conservation of the 5â² UTR is unexpected because mRNA translation in spermatids is thought to be regulated primarily by the 3â² UTR. Finally, all of the genes contain a single intron, implying that retroposons are rarely created from mRNAs that are expressed in spermatids.
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Authors
Kenneth C. Kleene, Jana Bagarova,