Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5912683 | Multiple Sclerosis and Related Disorders | 2014 | 8 Pages |
Abstract
We found that 7Â T MTR, in less than 10Â min scanning time, was able to detect cortical lesions. In this study we found that 7Â T MTR was better in detecting intracortical lesions in comparison with 7Â T T2â, 7Â T MPRAGE, and 3Â T 3D DIR. since only a very few intracortical lesions were detected in healthy controls in our blind assessment, it is likely that the lesions detected represent focal grey matter demyelination. High resolution MT imaging has especially revealed cortical changes that have not been recognised by other MR sequences. MTR maps were noisier than MPRAGE, T2â and DIR, but also better in localising cortical lesions. As MTR is more pathologically specific than other sequences in detecting tissue myelination, it raises the possibility that high resolution MTR will be able to demonstrate cortical remyelination in vivo.
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Authors
R. Abdel-Fahim, N. Mistry, O. Mougin, A. Blazejewska, A. Pitiot, R. Retkute, P. Gowland, N. Evangelou,