Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5913319 | Blood Cells, Molecules, and Diseases | 2016 | 11 Pages |
Abstract
The overactivation of TFH cells may contribute to the immunopathogenesis of pediatric ITP. IL-21 and IL-4 serum levels may affect the differentiation of TFH cells in ITP patients. The aberrant balance between BAFFR-BAFF/TACI-BAFF may be a factor that caused the persistent high expression of ICOSL in pediatric cITP, which consequently lead to the over activation of TFH cells in pediatric cITP.
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Authors
Xin Yao, Chengrong Li, Jun Yang, Guobing Wang, Changgang Li, Yu Xia,