Article ID Journal Published Year Pages File Type
5913319 Blood Cells, Molecules, and Diseases 2016 11 Pages PDF
Abstract
The overactivation of TFH cells may contribute to the immunopathogenesis of pediatric ITP. IL-21 and IL-4 serum levels may affect the differentiation of TFH cells in ITP patients. The aberrant balance between BAFFR-BAFF/TACI-BAFF may be a factor that caused the persistent high expression of ICOSL in pediatric cITP, which consequently lead to the over activation of TFH cells in pediatric cITP.
Related Topics
Life Sciences Biochemistry, Genetics and Molecular Biology Molecular Biology
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