Immunophenotyping with CD135 and CD117 predicts the FLT3, IL-7R and TLX3 gene mutations in childhood T-cell acute leukemia

Article ID	Journal	Published Year	Pages	File Type
5913414	Blood Cells, Molecules, and Diseases	2016	28 Pages	PDF

Abstract

We conclude that the addition of CD135 and CD117 to the diagnosis can predict molecular aberrations in T-ALL settings, mainly segregating patients with FLT3-ITD, who would benefit from treatment with inhibitors of tyrosine.

Keywords

CD117 EGIL B-cell precursor ALL AML TKD FLT3 mutations BCP-ALL PerCP BFM MoAb ITD MUT APC WBC FITC MFI TCr SSC allophycocyanin Monoclonal antibody T-ALL internal tandem duplication Multiparametric flow cytometry mutated Peripheral blood Tyrosine kinase domain median fluorescence intensity White blood cell count phycoerythrin acute myeloid leukemia T-cell acute lymphoblastic leukemia Acute lymphoblastic leukemia positive bone marrow negative wild type neg ALL side scatter pos T-cell receptor

Related Topics

Life Sciences Biochemistry, Genetics and Molecular Biology Molecular Biology

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Immunophenotyping with CD135 and CD117 predicts the FLT3, IL-7R and TLX3 gene mutations in childhood T-cell acute leukemia

Authors

Elda Pereira Noronha, Francianne Gomes Andrade, Carolina Zampier, Camilla F.C.G. de Andrade, EugÃªnia Terra-Granado, Maria S. Pombo-de-Oliveira,