| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5915373 | Molecular and Biochemical Parasitology | 2015 | 17 Pages |
Abstract
- Malaria parasites synthesize fatty acids in their apicoplast using a FASII pathway.
- FASII was considered a therapeutic drug target but was invalidated by genetic studies.
- Human malaria parasites and rodent models differ in their requirement for FASII.
- FASII might be a prophylactic target and other prospects remain for therapeutic drugs.
Keywords
DHAPAcpsPDHG3PDHCOAAcyl-coenzyme A synthetasePEPFOPACPACSApicoplastGFPPPTCyclohexanedioneACCDIMacetyl-coenzyme A carboxylaseFatty acidToxoplasmadihydroxyacetone phosphateendoplasmic reticulumGAPphosphoenolpyruvateLipidFASIIacyl carrier proteingreen fluorescent proteinPlasmodiumpyruvate dehydrogenasecoenzyme AFASIglycerol-3-phosphate acyltransferaseglycerol-3-phosphate dehydrogenase
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Authors
Melanie J. Shears, Cyrille Y. Botté, Geoffrey I. McFadden,