| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5915417 | Molecular and Biochemical Parasitology | 2014 | 9 Pages |
Abstract
- Cryptosporidium parvum has an active hypusine biosynthetic pathway.
- Unique modifications occur on translational elongation factor, eIF5A.
- It has single copy of deoxyhypusine synthase (DHS) unlike kinetoplastids.
- Km of CpDHS for eIF5A was higher than that of the human.
- Diamines and N-guanyl diamines inhibited C. parvum growth.
Keywords
Related Topics
Life Sciences
Biochemistry, Genetics and Molecular Biology
Molecular Biology
Authors
Nimisha Mittal, Marie Morada, Pankaj Tripathi, V.S. Gowri, Swati Mandal, Alison Quirch, Myung Hee Park, Nigel Yarlett, Rentala Madhubala,