| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5915460 | Molecular and Biochemical Parasitology | 2013 | 37 Pages |
Abstract
- Proteomic analysis showed 57 distinct proteins LbWTS vs LbSbR and LcWTS vs LcSbR.
- Proteins of antioxidant defense, stress and metabolism were differentially expressed.
- TRYP, α-tubulin, HSP70, HSP83, and HSP60 were overexpressed in LbSbR and LcSbR lines.
- CyPA is less expressed in LbSbR and LcSbR lines and PTR1 is higher in the LbSbR line.
- Mechanism of antimony-resistance in Leishmania spp. is complex and multifactorial.
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Authors
Fabiana S.V. Matrangolo, Daniel B. Liarte, Laila C. Andrade, Melina F. de Melo, Juvana M. Andrade, Rafael F. Ferreira, André S. Santiago, Carlos P. Pirovani, Rosiane A. Silva-Pereira, Silvane M.F. Murta,