Article ID Journal Published Year Pages File Type
5915503 Molecular and Biochemical Parasitology 2013 8 Pages PDF
Abstract
► The structure of TcPTP1 was solved at 2.18 Å resolution. ► The overall fold closely resembles those of the Trypanosoma brucei TbPTP1 and human PTP1B homologs. ► A secondary pocket situated adjacent to the active site could be targeted to develop specific bidentate inhibitors of TcPTP1.
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Life Sciences Biochemistry, Genetics and Molecular Biology Molecular Biology
Preview
Structure of the Trypanosoma cruzi protein tyrosine phosphatase TcPTP1, a potential therapeutic target for Chagas' disease
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