| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5915583 | Molecular and Biochemical Parasitology | 2012 | 9 Pages |
Abstract
⺠Trypanosomatids as well the mammalian host synthesize polyamines from arginine using a cytosolic type I arginase. ⺠Host macrophages can drive arginine to nitric oxide, a potent parasiticide intermediate. ⺠Host arginase/NOS response decides parasite survival/death, which is mediated by a Th2/Th1 response. ⺠Drugs inducing Th1 response or preventing arginase activity are good candidates for drug development.
Keywords
TrypanothioneOrnithine decarboxylaseTh1NTDNOS2ODCCATADCGP63TrpLPGRNOSSAMDCNω-hydroxy-l-arginineONOO−ROSS-adenosylmethionine decarboxylaseArginasearginine decarboxylaseAIDSneglected tropical diseasesR&DResearch and developmentTrypanosoma cruzicationic amino acid transporterinducible nitric oxide synthasephosphatidyl serineLipophosphoglycanNOHANitric oxidehuman immunodeficiency virusHIVHost responsePeroxynitritePolyaminesLeishmania spp.Reactive oxygen species
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Authors
Rafael Balaña-Fouce, EstefanÃa Calvo-Álvarez, Raquel Álvarez-Velilla, Christopher F. Prada, Yolanda Pérez-Pertejo, Rosa M. Reguera,