Trypanosoma brucei transferrin receptor can bind C-lobe and N-lobe fragments of transferrin

Article ID	Journal	Published Year	Pages	File Type
5915608	Molecular and Biochemical Parasitology	2012	7 Pages	PDF

Abstract

âº The T. brucei transferrin receptor binds its ligand via both C-lobe and N-lobe. âº Both C-lobe and N-lobe fragments support the growth of T. brucei bloodstream forms. âº The C-lobe is more efficiently taken up and more potent in supporting parasite growth.

Keywords

Concanavalin A Transferrin DAPI Trypanosoma brucei VSG ESAG human transferrin receptor 4,6-diamidino-2-phenylindole Con A Binding specificity Lactoferrin expression site-associated gene Iron acquisition Variant surface glycoprotein transferrin receptor

Related Topics

Life Sciences Biochemistry, Genetics and Molecular Biology Molecular Biology

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Trypanosoma brucei transferrin receptor can bind C-lobe and N-lobe fragments of transferrin

Authors

Dietmar Steverding, Darren W. Sexton, Nektaria Chrysochoidi, Fuyun Cao,