Article ID Journal Published Year Pages File Type
5915612 Molecular and Biochemical Parasitology 2012 10 Pages PDF
Abstract
► DED1 from yeast is essential for translation initiation. ► Each of the two Leishmania DED1s can complement the yeast ortholog. ► The function of LeishDED1-1 and LeishDED1-2 is redundant. ► The two LeishDED1s associate with the PIC through mRNA. ► Expression of the two LeishDED1s varies in the different life forms.
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Life Sciences Biochemistry, Genetics and Molecular Biology Molecular Biology
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Gene duplication in trypanosomatids - Two DED1 paralogs are functionally redundant and differentially expressed during the life cycle
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