| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5915720 | Molecular and Biochemical Parasitology | 2010 | 4 Pages |
Abstract
Although previous studies strongly suggested the involvement of serine proteases in blood digestion in the midgut of ticks, the regulating molecules of these proteinases are still unidentified. A novel Haemaphysalis longicornis Kunitz-type serine proteinase inhibitor with a single Kunitz-domain (HlMKI) has been identified and its co-localization with a midgut-derived serine proteinase (HlSP) within the epithelial cells has been demonstrated. Recombinant HlMKI inhibited the hydrolytic activity of HlSP, suggesting that HlMKI is a possible inhibitor of HlSP and may be part of a regulatory system of midgut serine proteinases.
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Authors
Takeharu Miyoshi, Naotoshi Tsuji, M. Khyrul Islam, M. Abdul Alim, Takeshi Hatta, Kayoko Yamaji, Anisuzzaman Anisuzzaman, Kozo Fujisaki,