| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5915735 | Molecular and Biochemical Parasitology | 2011 | 5 Pages |
Abstract
⺠Direct evidence of DNA mismatch repair activity in Plasmodium falciparum. ⺠Multi-drug resistant parasite strains possess defective DNA mismatch repair. ⺠Lack of PfMLH1 expression is the source of mismatch repair deficiency for W2 strain parasites. ⺠This study provides an exciting new hypothesis to explain the underlying mechanisms of P. falciparum drug resistance.
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Authors
Meryl A. Castellini, Jeffrey S. Buguliskis, Louis J. Casta, Charles E. Butz, Alan B. Clark, Thomas A. Kunkel, Theodore F. Taraschi,