A schizont-derived protein, TpSCOP, is involved in the activation of NF-ÎºB in Theileria parva-infected lymphocytes

Article ID	Journal	Published Year	Pages	File Type
5915814	Molecular and Biochemical Parasitology	2010	10 Pages	PDF

Abstract

We characterize a novel protein derived from a lymphocyte-transforming Theileria. Introduction of TpSCOP into mammalian cells resulted in the activation of NF-ÎºB and MAPK pathway, leading to resistance to apoptosis.

Keywords

ERK NF-κB RT-PCR Jnk mAb FBS IKK AICD IPTG TCr GST PIM c-Jun N-terminal kinase MAPK Monoclonal antibody sodium dodecyl sulfate-polyacrylamide gel electrophoresis SDS-PAGE actin Theileria parva Apoptosis fetal bovine serum Nuclear factor-kappa B activation-induced cell death reverse transcription-polymerase chain reaction polymerase chain reaction PCR mitogen-activated protein kinase Propidium iodide extracellular signal-regulated kinase glutathione S-transferase T-cell receptor

Related Topics

Life Sciences Biochemistry, Genetics and Molecular Biology Molecular Biology

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A schizont-derived protein, TpSCOP, is involved in the activation of NF-ÎºB in Theileria parva-infected lymphocytes

Authors

Kyoko Hayashida, Masakazu Hattori, Ryo Nakao, Yoshimasa Tanaka, Jung-Yeon Kim, Noboru Inoue, Vishvanath Nene, Chihiro Sugimoto,