| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5915829 | Molecular and Biochemical Parasitology | 2010 | 14 Pages |
Abstract
African trypanosomes de novo synthesise all major glycerophospholipid and sphingolipid classes. Possible differences between trypanosome and mammalian lipid biosynthetic pathways could be exploited for the development of drugs against the diseases caused by these parasites.
Keywords
EPCinositol phosphorylceramideFatty acyl-CoA synthetaseGPI-PLCPLA1SMasePGPGPiIPCCOAACSSLSpIPSsphingolipidssphingomyelinsphingomyelinaseFatty acidsBiosynthesisTrypanosomadiacylglycerolDAGendoplasmic reticulumphosphatidylinositolphosphatidylcholinephosphatidylglycerophosphatephosphatidylglycerolphosphatidylethanolaminePhosphatidylserinePhospholipase A1PhospholipidsMetabolismCardiolipincoenzyme Aglycosylphosphatidylinositol
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Authors
Terry K. Smith, Peter Bütikofer,