| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5915975 | Molecular and Biochemical Parasitology | 2009 | 8 Pages |
Abstract
Cysteine peptidases are important for growth and survival of kinetoplastid parasites. The best characterised are those homologous to mammalian cathepsins B and L. To address a somewhat confusing terminology, we introduce a unifying nomenclature for kinetoplastid CATB and CATL peptidases. We review their evolutionary relatedness, genomic organisation, developmental expression, subcellular location and physiological functions. In addition, the applications of kinetoplastid CATB and CATL enzymes as vaccine candidates, diagnostic markers and drug targets are discussed.
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Authors
Conor R. Caffrey, Dietmar Steverding,