Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5916218 | Molecular and Biochemical Parasitology | 2007 | 11 Pages |
Abstract
The availability of Rahman, and the virulent HM-1:IMSS strain of E. histolytica, provides a powerful tool for identifying virulence factors of E. histolytica. Here we report an attempt to identify potential virulence factors of E. histolytica by comparing the transcriptome of E. histolytica HM-1:IMSS and E. histolytica Rahman. With phenotypically defined strains, we compared the transcriptome of Rahman and HM-1:IMSS using a custom 70mer oligonucleotide based microarray that has essentially full representation of the E. histolytica HM-1:IMSS genome. We find extensive differences between the two strains, including distinct patterns of gene expression of cysteine proteinases, AIG family members, and lectin light chains.
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Authors
Paul H. Davis, Jochen Schulze, Samuel L. Jr.,