Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5916505 | Molecular Immunology | 2015 | 9 Pages |
Abstract
Our results suggested that soluble MSU, but not MSU crystals, induce NLRP3, IL-1β, HLA-DR and CD40 upregulation in a TLR4-dependent manner. These findings indicate that soluble MSU may play a pathological role in hyperuricemia induced renal mesangial injury.
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Authors
Xiao Jing, Fu Chensheng, Zhang Xiaoli, Zhu Dingyu, Chen Weijun, Lu Yijun, Ye Zhibin,