| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5916888 | Molecular Immunology | 2014 | 10 Pages |
Abstract
Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by the production of autoantibodies. This review summarizes first the results obtained in the mouse that have revealed how B cell tolerance is breached in SLE. We then review the B cell subsets, in addition to the autoAb producing cells, which contribute to SLE pathogenesis, focusing on marginal zone B cells, B-1 cells and regulatory B cells. Finally, we review the interactions between B cells and other immune cells that have been implicated in SLE, such as dendritic cells, macrophages, neutrophils and T cells.
Keywords
Marginal zone B cellsTFHICOSPMNMDCAFCmAbSHMBCRpDCsMonoclonal antibodysomatic hypermutationTransgenicneutrophil extracellular trapsNETautoimmunitydelta-like 1myeloid DCapoptotic cellDendritic cellB cellsFollicular helper T cellsFollicular B cellsAntibody forming cellsplasma cellplasmacytoid dendritic cellsfollicleLupusSystemic lupus erythematosusSLEimmune complexGerminal centermarginal zonepolymorphonuclear neutrophilAntibodyAntigenSingle nucleotide polymorphismSNPAIDGlomerulonephritisB cell receptor
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Authors
Allison Sang, Ying-Yi Zheng, Laurence Morel,