Article ID Journal Published Year Pages File Type
5917043 Molecular Immunology 2014 8 Pages PDF
Abstract

- LTA of Streptococcus mutans (Sm.LTA) has a modest immuno-stimulatory potential.
- Sm.LTA preferentially binds to and stimulates cells expressing TLR2 and CD14.
- Sm.LTA does not stimulate macrophages derived from TLR2-deficient mice.
- Deacylated Sm.LTA neither stimulates TLR2 nor induces inflammatory mediators.
- Sm.LTA interacts with TLR2 through its lipid moiety for induction of inflammation.
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Life Sciences Biochemistry, Genetics and Molecular Biology Molecular Biology
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Lipoteichoic acid of Streptococcus mutans interacts with Toll-like receptor 2 through the lipid moiety for induction of inflammatory mediators in murine macrophages
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