Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5917292 | Molecular Immunology | 2013 | 4 Pages |
Abstract
⺠A subset of MHC-I peptides is generated by alternative processing routes, independent of proteasome and TAP. ⺠A broad and unique peptide repertoire is presented on TAP-deficient cells. ⺠Several processing pathways deliver these TAP-independent peptides. ⺠We are unraveling a novel route that depends on membrane-associated proteolysis and macro-authophagy.
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Authors
Claudia C. Oliveira, Thorbald van Hall,