Article ID Journal Published Year Pages File Type
5917298 Molecular Immunology 2013 5 Pages PDF
Abstract
► Folding, peptide binding, and transport rates differ markedly between MHC class I allotypes. ► It is important to understand class I maturation and transport as a contribution to immunodominance. ► Pulse-chase experiments in principle offer much information on folding, maturation, and ER-Golgi transport of class I. ► The review demonstrates their potential and advises how to avoid common pitfalls.
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