{[[K.18-Crown-6]Br3}n: A tribromide catalyst for the catalytic protection of amines and alcohols

{[K.18-Crown-6]Br3}n, a unique tribromide-type catalyst, was utilized for the N-boc protection of amines and trimethylsilylation (TMS) and tetrahydropyranylation (THP) of alcohols. The method is general for the preparation of N-boc derivatives of aliphatic (acyclic and cyclic) and aromatic, and primary and secondary amines and also various TMS-ethers and THP-ethers. The simple separation of the catalyst from the product is one of the many advantages of this method.

Graphical Abstract{[K.18-Crown-6]Br3}n as a unique tribromide-type catalyst was utilized for the N-boc protection of amines and the trimethylsilylation/tetrahydropyranylation of alcohols. The simple separation of the catalyst from the products is only one of the many advantages of this method.Figure optionsDownload full-size imageDownload as PowerPoint slide