| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5917352 | Molecular Immunology | 2012 | 9 Pages |
Abstract
⺠Aberrant intra-epithelial lymphocytes (IELs) are the hallmark of refractory coeliac disease type II RCDII. ⺠Our data indicates that aberrant IELs in duodenal biopsies of RCDII patients originate from deranged developing precursor T-lymphocytes, while the various populations display heterogeneous TCR gene rearrangements, but all contain high levels of granzyme B. ⺠Only patients harboring the most mature aberrant IEL population developed an EATL. ⺠TCR-beta gene rearrangement analysis in addition to phenotypical identification of aberrant IELs could be useful to identify at risk aberrant IEL population.
Keywords
FITCTCRDPCNATcrbsCD25enteropathy associated t-cell lymphomaEATLRCDTCRAPerCPNKG2DGFDTdTFACSMFIIELAPCTCrnatural killerallophycocyaninProliferating Cell Nuclear AntigenOriginCoeliac diseaseterminal deoxynucleotidyl transferaseGluten free dietphycoerythrinfluorescein isothiocyanatefluorescence activated cell sorterIntraepithelial lymphocyterefractory coeliac diseasemean fluorescence intensityperidinin chlorophyll proteinT-cell receptor
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Authors
Greetje J. Tack, Roy L.J. van Wanrooij, Anton W. Langerak, Jennifer M.L. Tjon, B. Mary E. von Blomberg, Danielle A.M. Heideman, Jeroen van Bergen, Frits Koning, Gerd Bouma, Chris J.J. Mulder, Marco W.J. Schreurs,