Zymosan activates protein kinase A via adenylyl cyclase VII to modulate innate immune responses during inflammation

Article ID	Journal	Published Year	Pages	File Type
5917359	Molecular Immunology	2013	9 Pages	PDF

Abstract

âº Zymosan particles increase cAMP and activation of PKA in macrophage cells. âº These responses depend on AC7 and heterotrimeric G proteins, primarily G12/13. âº Macrophage cells deficient of AC7 produce more TNFÎ± in response to zymosan. âº Mice without myeloid AC7 show prolonged inflammation in zymosan induced peritonitis.

Keywords

S1P G13 P3C BMDM YFP pKa PGE2 LBP cAMP adenylyl cyclase Sphingosine-1-phosphate bioluminescence resonance energy transfer BRET renilla luciferase Zymosan bone marrow derived macrophages yellow fluorescent protein protein kinase A Prostaglandin E2