| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5917360 | Molecular Immunology | 2013 | 9 Pages |
Abstract
⺠SLE patients overexpress ZAS3 and estrogen up-regulates ZAS3 in human cells. ⺠Estrogen treatment up-regulates ZAS3 in mouse lymphoid tissue. ⺠ERα transactivates ZAS3 by binding within the ZAS3 locus. ⺠Blocking ERα, but not IFNα, prevents estrogen stimulation of ZAS3. ⺠ZAS3 overexpression may account for bone pathology and NFκB inhibition seen in SLE.
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Authors
Nicholas A. Young, Alexandra K. Friedman, Benjamin Kaffenberger, Murugesan V.S. Rajaram, Daniel J. Birmingham, Brad H. Rovin, Lee A. Hebert, Larry S. Schlesinger, Lai-Chu Wu, Wael N. Jarjour,