| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5917416 | Molecular Immunology | 2012 | 8 Pages |
Abstract
⺠Afucosylated rituximab expressed in Lemna was composed of a single major N-glycan species (GnGn) without detectable fucose or xylose. ⺠Target cell binding and apoptosis induction were similar between the afucosylated rituximab and rituximab. ⺠Antibody-dependent cellular cytotoxicity (ADCC) and B-cell depletion was increased by the afucosylated rituximab. ⺠Complement-dependent cytotoxicity (CDC) was attenuated by the afucosylated rituximab. ⺠The higher ADCC and B-cell depletion suggest a potential improvement in efficacy and potency, while lower CDC may mitigate infusion toxicity.
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Authors
John R. Gasdaska, Steven Sherwood, Jeffrey T. Regan, Lynn F. Dickey,