| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5917444 | Molecular Immunology | 2011 | 13 Pages |
Abstract
⺠Three novel Anas platyrhynchos avian β-defensins (Apl_AvBDs) were identified successfully and characterized in tissues from Peking ducks. ⺠Both recombinant and synthetic forms of the three Apl_AvBDs showed antibacterial activity against most of the bacteria investigated. ⺠Significant antiviral activity of the three Apl_AvBDs was shown against duck hepatitis virus (DHV). However, none of the Apl_AvBDs showed significant hemolytic activity. ⺠Expression of the three Apl_AvBDs showed different levels in different tissues of ducklings at different time points after DHV infection. ⺠The present results demonstrate that Apl_AvBDs play vital roles in the immune response of ducks against bacterial and viral pathogens.
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Authors
Deying Ma, Lijuan Lin, Kexin Zhang, Zongxi Han, Yuhao Shao, Xiaoli Liu, Shengwang Liu,