| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5917468 | Molecular Immunology | 2011 | 10 Pages |
Abstract
⺠The early pulmonary response to migrating lung schistosomula is characteristic of innate inflammation and wound healing. ⺠This response is associated with significant up-regulation of chemokine genes that direct cell recruitment. ⺠This response is associated with significant up-regulation of several genes with immunoregulatory function, including Ch25h, Hmox1 and Retnla. ⺠This knowledge contributes to our understanding of host-parasite interactions associated with schistosome infection and may aid the future design of novel vaccines that target the lung stage schistosomula.
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Authors
Melissa L. Burke, Laken McGarvey, Henry J. McSorley, Helle Bielefeldt-Ohmann, Donald P. McManus, Geoffrey N. Gobert,