| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5917480 | Molecular Immunology | 2011 | 14 Pages |
Abstract
⺠Truncated forms of TCRβ target mitochondria and induce apoptosis. ⺠Residues flanking the TMD of TCRβ are inessential for its mitochondrial targeting. ⺠The isolated TMD of TCRβ is a sufficient mitochondrial-targeting signal. ⺠Any TCRβ truncation, leaving an intact TMD, causes mitochondrial targeting. ⺠Mitochondria are a sequestration site for impaired TCR molecules.
Keywords
Related Topics
Life Sciences
Biochemistry, Genetics and Molecular Biology
Molecular Biology
Authors
Nir Shani, Vera Shinder, Dov Zipori,