| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5917596 | Molecular Immunology | 2009 | 8 Pages |
Abstract
Therefore, we modelled the three-dimensional structure of CXCL9 and CXCR3, and, successively, of the CXCL9/CXCR3 complex in comparison to CXCL10/CXCR3 and CXCL11/CXCR3 complexes. We have then shown the structural determinants of these interactions and their physico-chemical features. Finally, the interaction residues involved in the formation of the complexes have been highlighted and analyzed in order to be used for drug design.
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Authors
Tiziana Trotta, Susan Costantini, Giovanni Colonna,