| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5917760 | Molecular Immunology | 2011 | 9 Pages |
Abstract
⺠We examined the changes of the expression level of surface molecules on dendritic cells (DCs) upon co-culture with various cancer cell lines. ⺠DCs co-cultured with Jurkat, but not MCF 7, showed down-regulation of LMP7, TAP2 and β2-microglobulin and MHC I molecules by a direct cell-cell interaction. ⺠DCs that had been herpes simplex virus-treated and co-cultured with Jurkat cells showed a reduced potency to activate CD8+ T cells.
Keywords
APMβ2MGM-CSFDCsLMPHSVCTLPBMCLPSCD8+ T cellsβ2-microglobulintransporter associated with antigen processingperipheral blood mononuclear cellsDendritic cellsCancer cellsTAPGranulocyte macrophage colony stimulating factorcytotoxic T lymphocytelipopolysaccharideAntigen processing machinerymajor histocompatibility complexmean fluorescence intensityherpes simplex virus
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Authors
Min Ji Seo, Gi Rak Kim, Young Min Son, Deok-Chun Yang, Hyuk Chu, Tae Sun Min, In Duk Jung, Yeong-Min Park, Seung Hyun Han, Cheol-Heui Yun,