Carbon monoxide, a reaction product of heme oxygenase-1, suppresses the expression of C-reactive protein by endoplasmic reticulum stress through modulation of the unfolded protein response

Article ID	Journal	Published Year	Pages	File Type
5917766	Molecular Immunology	2011	7 Pages	PDF

Abstract

âº Endoplasmic reticulum stress induces the expression of C-reactive protein in HepG2 cells. âº Carbon monoxide modulates endoplasmic reticulum stress. âº Carbon monoxide inhibits C-reactive protein expression by endoplasmic reticulum stress.

Keywords

protein kinase R-like endoplasmic reticulum kinase CORM-3 CREBH CORM-2 HO-1 XBP-1 Hcys 4-PBA tunicamycin UPR TUDCA Thapsigargin ATF6 Heme oxygenase-1 IRE1α Endoplasmic reticulum stress 4-phenylbutyric acid Tauroursodeoxycholic acid Serum amyloid P component endoplasmic reticulum SAP activating transcription factor 6 carbon monoxide homocysteine Unfolded protein response C-reactive protein CRP PERK