| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5917842 | Molecular Immunology | 2011 | 9 Pages |
Abstract
⺠In this study, we demonstrated that SUMO-2 directly modified IκBα. ⺠Further, we examined the effect of SUMO-2 on the phenotypic changes of mature dendritic cells. ⺠We found that IL-12 secretion from mature dendritic cells can be down-regulated by SUMO-2 overexpression. ⺠Also, SUMO-2 overexpressing dendritic cells shift naïve CD4+ T cells to Th2 type response in vitro. ⺠The results of this study may be applied to the development of novel gene therapy strategies for tolerance induction during allogeneic responses.
Keywords
T helper type 1LPSSENPSUMOylationSUMOTh1IL-12C57BL/6NFκBElectrophoretic mobility shift assaypost-translational modificationchromatin immunoprecipitationinterleukin-12NK cellDendritic cellNatural killer cellDendritic cellsEMSA یا electrophoretic mobility shift assay lipopolysaccharidemajor histocompatibility complexMHCCHiPcomplete mediumsmall ubiquitin-like modifier
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Authors
Eun Mi Kim, Han-Hyoung Lee, Sang-Hoon Kim, Young-Ok Son, Suk Jun Lee, Jihye Han, Joonbeom Bae, Sang Joon Kim, Chung-Gyu Park, Yongsoo Park, Kwang Woo Hwang, Taehoon Chun,