Blocking lymphotoxin beta receptor signalling exacerbates acute DSS-induced intestinal inflammation-Opposite functions for surface lymphotoxin expressed by T and B lymphocytes

All these modes of LTβR signalling ablation resulted in significant aggravation of the disease and in release of inflammatory cytokines such as TNF, IL-6, and IFNγ. Finally, using mice with conditionally ablated expression of membrane bound LTβ on T or B cells, respectively, distinct and opposite contributions of surface LTβ expressed on T or B cells was found. Thus, activation of LTβR by LTαβ mainly expressed on T lymphocytes is crucial for the down regulation of the inflammatory response in this experimental model.