Nodavirus increases the expression of Mx and inflammatory cytokines in fish brain

For comparative purposes, we analyzed the expression of the same genes on a susceptible species, such as sea bass (Dicentrarchus labrax) and, although the same pattern of expression was observed both in brain and kidney, the magnitude was different mainly in the case of brain, the key organ of the infection, where higher expression of TNFα and lower expression of Mx compared with control was observed.