A Rapid and Green Method for Solvent-Free Synthesis of 1,8-Dioxodecahydroacridines Using Tetrabutylammonium Hexatungstate as a Reusable Heterogeneous Catalyst

Tetrabutylammonium hexatungstate, [TBA]2[W6O19], has been used as an efficient, inexpensive, and recyclable green catalyst for the one-pot three-component synthesis of 1,8-dioxodecahydroacridines by the reaction of dimedone with aromatic or aliphatic aldehydes in the presence of a nitrogen source (ammonium acetate or aromatic amines) under neat conditions. There are several advantages to the current process over the standard procedures available in the literature, including shorter reaction times (7–14 min), higher yields, facile work-up, and minimal environmental impact. Furthermore, the catalyst can be conveniently recovered and reused.

Graphical abstractTetrabutylammonium hexatungstate, [TBA]2[W6O19], has been used as an efficient catalyst for the synthesis of 1,8-dioxodecahydroacridines under solvent-free conditions. There are several key advantages to the current procedure over the standard procedures available in the literature, including shorter reaction times, higher yields, facile workup, and reusability of the catalyst.Figure optionsDownload full-size imageDownload as PowerPoint slide